MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation
نویسندگان
چکیده
منابع مشابه
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations
Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery endothelial cell (PAEC) proliferation, apoptosis and permeability. Loss-of-function mutations in the bone morphogenetic protein receptor type-II (BMPR-II) are the most common cause of heritable PAH, usually resulting in haploinsufficiency. We previously showed that BMPR-II expression is regulated via a lysos...
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ژورنال
عنوان ژورنال: Vascular Pharmacology
سال: 2016
ISSN: 1537-1891
DOI: 10.1016/j.vph.2016.07.001